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Livres
Articles (42)
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The alternative pathway is required, but not alone sufficient, for retinal pathology in mouse laser-induced choroidal neovascularization

Bärbel Rohrer, Beth Coughlin, Kannan Kunchithapautham, Qin Long, Stephen Tomlinson, Kazue Takahashi, V. Michael Holers

Journal:

Molecular Immunology

Année:

2011

Langue:

english

Fichier:

PDF, 854 KB

english, 2011

Multiple, parallel cellular suicide mechanisms participate in photoreceptor cell death

Heather R. Lohr, Kannan Kuntchithapautham, Ashish K. Sharma, Bärbel Rohrer

Journal:

Experimental Eye Research

Année:

2006

Langue:

english

Fichier:

PDF, 436 KB

english, 2006

Erratum to “Multiple, parallel cellular suicide mechanisms participate in photoreceptor cell death” [Exp. Eye Res. 83 (2006) 380–389]

Heather R. Lohr, Kannan Kuntchithapautham, Ashish K. Sharma, Bärbel Rohrer

Journal:

Experimental Eye Research

Année:

2006

Langue:

english

Fichier:

PDF, 64 KB

english, 2006

Classical complement activation and acquired immune response pathways are not essential for retinal degeneration in the rd1 mouse

Bärbel Rohrer, Christina Demos, Rico Frigg, Christian Grimm

Journal:

Experimental Eye Research

Année:

2007

Langue:

english

Fichier:

PDF, 2.05 MB

english, 2007

Alternative complement pathway signalling in a mouse model of choroidal neovascularisation

Bärbel Rohrer, Qin Long, Brooks Wilson, Beth Coughlin, Yuxiang Huang, Fei Qiao, Peter Tang, Kannan Kunchithapautham, Gary Gilkeson, Stephen Tomlinson

Journal:

Molecular Immunology

Année:

2008

Langue:

english

Fichier:

PDF, 70 KB

english, 2008

Oxidative stress renders retinal epithelial cells susceptible to complement mediated injury

Bärbel Rohrer, Brandon Renner, Kannan Kunchithapautham, Zsolt Ablonczy, Stephen Tomlinson, Joshua Thurman

Journal:

Molecular Immunology

Année:

2008

Langue:

english

Fichier:

PDF, 70 KB

english, 2008

Prolonged voltage-gated calcium channel activation by sublytic complement activation in retinal pigment epithelium, a mechanism for controlling VEGF secretion

Bärbel Rohrer, Kannan Kunchithapautham, Andreas Genewski, Olaf Strauss

Journal:

Immunobiology

Année:

2012

Langue:

english

Fichier:

PDF, 83 KB

english, 2012

Novel monoclonal antibodies to C3d that target and identify in living animals sites of complement activation

Joshua M. Thurman, Liudmila Kulik, Lynne M. Mitchell, Dennis E. Hourcade, Jonathan P. Hannan, Beth Coughlin, Alex S. Woodell, Matthew C. Pickering, Barbel Rohrer, Michael Holers

Journal:

Immunobiology

Année:

2012

Langue:

english

Fichier:

PDF, 68 KB

english, 2012

Sustained Elevation of Intracellular cGMP Causes Oxidative Stress Triggering Calpain-Mediated Apoptosis in Photoreceptor Degeneration

Sharma, Ashish K., Rohrer, Bärbel

Journal:

Current Eye Research

Année:

2007

Langue:

english

Fichier:

PDF, 1.73 MB

english, 2007

Systemic Human CR2-Targeted Complement Alternative Pathway Inhibitor Ameliorates Mouse Laser-Induced Choroidal Neovascularization

Rohrer, Bärbel, Coughlin, Beth, Bandyopadhyay, Mausumi, Holers, V. Michael

Journal:

Journal of Ocular Pharmacology and Therapeutics

Année:

2012

Langue:

english

Fichier:

PDF, 277 KB

english, 2012

Revealing functionally coherent subsets using a spectral clustering and an information integration approach

Adam J Richards, John H Schwacke, Bärbel Rohrer, L Ashley Cowart…

Journal:

BMC Systems Biology

Année:

2012

Langue:

english

Fichier:

PDF, 535 KB

english, 2012

Algorithm-Based Cholesterol Monitoring in Children with Type 1 Diabetes

Schwab, K. Otfried, Doerfer, Jürgen, Scheidt-Nave, Christa, Kurth, Bärbel-Maria, Hungele, Andreas, Scheuing, Nicole, Krebs, Andreas, Dost, Axel, Rohrer, Tilman R., Schober, Edith, Holl, Reinhard W.

Journal:

The Journal of Pediatrics

Année:

2014

Langue:

english

Fichier:

PDF, 171 KB

english, 2014

Sublytic Membrane-Attack-Complex (MAC) Activation Alters Regulated Rather than Constitutive Vascular Endothelial Growth Factor (VEGF) Secretion in Retinal Pigment Epithelium Monolayers

Kunchithapautham, Kannan, Rohrer, Bärbel

Journal:

Journal of Biological Chemistry

Année:

2011

Langue:

english

Fichier:

PDF, 1.58 MB

english, 2011

A comparative analysis of C57BL/6J and 6N substrains; chemokine/cytokine expression and susceptibility to laser-induced choroidal neovascularization

Schnabolk, Gloriane, Stauffer, Kimberly, O'Quinn, Elizabeth, Coughlin, Beth, Kunchithapautham, Kannan, Rohrer, Bärbel

Journal:

Experimental Eye Research

Année:

2014

Langue:

english

Fichier:

PDF, 478 KB

english, 2014

Quantitative analysis of mitochondrial morphology and membrane potential in living cells using high-content imaging, machine learning, and morphological binning

Leonard, Anthony P., Cameron, Robert B., Speiser, Jaime L., Wolf, Bethany J., Peterson, Yuri K., Schnellmann, Rick G., Beeson, Craig C., Rohrer, Bärbel

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Année:

2015

Langue:

english

Fichier:

PDF, 2.22 MB

english, 2015

Apoptosis and Autophagy in Photoreceptors Exposed to Oxidative Stress

Kunchithapautham, Kannan, Rohrer, Bärbel

Journal:

Autophagy

Année:

2007

Langue:

english

Fichier:

PDF, 539 KB

english, 2007

Activation of endogenously expressed ion channels by active complement in the retinal pigment epithelium

Genewsky, Andreas, Jost, Ingmar, Busch, Catharina, Huber, Christian, Stindl, Julia, Skerka, Christine, Zipfel, Peter F., Rohrer, Bärbel, Strauß, Olaf

Journal:

Pflügers Archiv European Journal of Physiology

Année:

2015

Langue:

english

Fichier:

PDF, 1.15 MB

english, 2015

Matrix Metalloproteinase Activity Creates Pro-Angiogenic Environment in Primary Human Retinal Pigment Epithelial Cells Exposed to Complement

Bandyopadhyay, Mausumi, Rohrer, Bärbel

Journal:

Investigative Ophthalmology & Visual Science

Année:

2012

Langue:

english

Fichier:

PDF, 447 KB

english, 2012

The Role of the Immune Response in Age-Related Macular Degeneration

Whitcup, Scott M., Sodhi, Akrit, Atkinson, John P., Holers, V. Michael, Sinha, Debasish, Rohrer, Bärbel, Dick, Andrew D.

Journal:

International Journal of Inflammation

Année:

2013

Langue:

english

Fichier:

PDF, 309 KB

english, 2013

Autophagy is One of the Multiple Mechanisms Active in Photoreceptor Degeneration

Kunchithapautham, Kannan, Rohrer, Bärbel

Journal:

Autophagy

Année:

2007

Langue:

english

Fichier:

PDF, 254 KB

english, 2007

New therapeutic and diagnostic opportunities for injured tissue-specific targeting of complement inhibitors and imaging modalities

Holers, V. Michael, Tomlinson, Stephen, Kulik, Liudmila, Atkinson, Carl, Rohrer, Bärbel, Banda, Nirmal, Thurman, Joshua M.

Journal:

Seminars in Immunology

Année:

2016

Langue:

english

Fichier:

PDF, 1.14 MB

english, 2016

Connecting the innate and adaptive immune responses in mouse choroidal neovascularization via the anaphylatoxin C5a and γδT-cells

Coughlin, Beth, Schnabolk, Gloriane, Joseph, Kusumam, Raikwar, Himanshu, Kunchithapautham, Kannan, Johnson, Krista, Moore, Kristi, Wang, Yi, Rohrer, Bärbel

Journal:

Scientific Reports

Année:

2016

Langue:

english

Fichier:

PDF, 929 KB

english, 2016

Targeting the tight junction protein, zonula occludens-1, with the connexin43 mimetic peptide, αCT1, reduces VEGF-dependent RPE pathophysiology

Obert, Elisabeth, Strauss, Randy, Brandon, Carlene, Grek, Christina, Ghatnekar, Gautam, Gourdie, Robert, Rohrer, Bärbel

Journal:

Journal of Molecular Medicine

Année:

2017

Langue:

english

Fichier:

PDF, 1.65 MB

english, 2017

Bystander effects elicited by single-cell photo-oxidative blue-light stimulation in retinal pigment epithelium cell networks

Ishii, Masaaki, Rohrer, Bärbel

Journal:

Cell Death Discovery

Année:

2017

Langue:

english

Fichier:

PDF, 3.57 MB

english, 2017

New Insights on Complement Inhibitor CD59 in Mouse Laser-Induced Choroidal Neovascularization: Mislocalization After Injury and Targeted Delivery for Protein Replacement

Schnabolk, Gloriane, Beon, Mee Keong, Tomlinson, Stephen, Rohrer, Bärbel

Journal:

Journal of Ocular Pharmacology and Therapeutics

Année:

2017

Langue:

english

Fichier:

PDF, 701 KB

english, 2017

The exocyst is required for photoreceptor ciliogenesis and retinal development

Lobo, Glenn P, Fulmer, Diana, Guo, Lilong, Zuo, Xiaofeng, Dang, Yujing, Kim, Seok-Hyung, Su, Yanhui, George, Kola, Obert, Elisabeth, Fogelgren, Ben, Nihalani, Deepak, Norris, Russell A, Rohrer, Bärbel

Journal:

Journal of Biological Chemistry

Année:

2017

Langue:

english

Fichier:

PDF, 3.54 MB

english, 2017

Alginate Microcapsule Technology and Impacts on Cell Therapy Development

Belhaj, Marwa, Menon, Vinal, Rohrer, Barbel, Potts, Jay

Journal:

Microscopy and Microanalysis

Année:

2017

Langue:

english

Fichier:

PDF, 122 KB

english, 2017

Delivery of CR2-fH using AAV vector therapy and encapsulated cell technology as treatment strategies in mouse model of neovascularization

Rohrer, Bärbel, Schnabolk, Gloriane, Annamalei, Balasubramaniam, Parsons, Nathanial, Potts, Jay, Lewin, Alfred, Tomlinson, Stephen M.

Journal:

Molecular Immunology

Année:

2017

Langue:

english

Fichier:

PDF, 48 KB

english, 2017

The Retinol Binding Protein Receptor 2 (Rbpr2) is required for Photoreceptor Outer Segment Morphogenesis and Visual Function in Zebrafish

Shi, Yi, Obert, Elisabeth, Rahman, Bushra, Rohrer, Bärbel, Lobo, Glenn P.

Journal:

Scientific Reports

Année:

2017

Langue:

english

Fichier:

PDF, 2.81 MB

english, 2017

Delivery of CR2-fH Using AAV Vector Therapy as Treatment Strategy in the Mouse Model of Choroidal Neovascularization

Schnabolk, Gloriane, Parsons, Nathaniel, Obert, Elisabeth, Annamalai, Balasubramaniam, Nasarre, Cecile, Tomlinson, Stephen, Lewin, Alfred S., Rohrer, Bärbel

Journal:

Molecular Therapy — Methods & Clinical Development

Année:

2018

Langue:

english

Fichier:

PDF, 1.47 MB

english, 2018

Mechanisms of bystander effects in retinal pigment epithelium cell networks

Ishii, Masaaki, Rohrer, Bärbel

Journal:

Cell Death and Disease

Année:

2017

Langue:

english

Fichier:

PDF, 437 KB

english, 2017

Extracellular vesicle-mediated long-range communication in stressed retinal pigment epithelial cell monolayers

Shah, Navjot, Ishii, Masakii, Brandon, Carlene, Ablonczy, Zsolt, Cai, Jingwen, Liu, Yutao, Chou, C. James, Rohrer, Bärbel

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Année:

2018

Langue:

english

Fichier:

PDF, 2.55 MB

english, 2018

Local Production of the Alternative Pathway Component Factor B Is Sufficient to Promote Laser-Induced Choroidal Neovascularization

Schnabolk, Gloriane, Coughlin, Beth, Joseph, Kusumam, Kunchithapautham, Kannan, Bandyopadhyay, Mausumi, O'Quinn, Elizabeth C., Nowling, Tamara, Rohrer, Bärbel

Journal:

Investigative Opthalmology & Visual Science

Année:

2015

Langue:

english

Fichier:

PDF, 1003 KB

english, 2015

Gene Therapy Rescues Cone Structure and Function in the 3-Month-Old rd12 Mouse: A Model for Midcourse RPE65 Leber Congenital Amaurosis

Li, Xia, Li, Wensheng, Dai, Xufeng, Kong, Fansheng, Zheng, Qinxiang, Zhou, Xiangtian, Lü, Fan, Chang, Bo, Rohrer, Bärbel, Hauswirth, William. W., Qu, Jia, Pang, Ji-jing

Journal:

Investigative Ophthalmology & Visual Science

Année:

2011

Langue:

english

Fichier:

PDF, 2.19 MB

english, 2011

Differential Effects of Rapamycin on Rods and Cones During Light-Induced Stress in Albino Mice

Kunchithapautham, Kannan, Coughlin, Beth, Lemasters, John J., Rohrer, Bärbel

Journal:

Investigative Ophthalmology & Visual Science

Année:

2011

Langue:

english

Fichier:

PDF, 1.72 MB

english, 2011

Encapsulated Cell Technology-Based Delivery of a Complement Inhibitor Reduces Choroidal Neovascularization in a Mouse Model

Annamalai, Balasubramaniam, Parsons, Nathaniel, Belhaj, Marwa, Brandon, Carlene, Potts, Jay, Rohrer, Bärbel

Journal:

Translational Vision Science & Technology

Année:

2018

Langue:

english

Fichier:

PDF, 1022 KB

english, 2018

Correction: Mechanisms of bystander effects in retinal pigment epithelium cell networks

Ishii, Masaaki, Rohrer, Bärbel

Journal:

Cell Death and Disease

Année:

2018

Langue:

english

Fichier:

PDF, 201 KB

english, 2018

Inhibition of the alternative complement pathway accelerates repair processes in the murine model of choroidal neovascularization

Parsons, Nathaniel, Annamalai, Balasubramaniam, Obert, Elisabeth, Schnabolk, Gloriane, Tomlinson, Stephen, Rohrer, Bärbel

Journal:

Molecular Immunology

Année:

2019

Fichier:

PDF, 1.44 MB

2019

A Targeted Inhibitor of the Alternative Complement Pathway Accelerates Recovery From Smoke-Induced Ocular Injury

Woodell, Alex, Jones, Bryan W., Williamson, Tucker, Schnabolk, Gloriane, Tomlinson, Stephen, Atkinson, Carl, Rohrer, Bärbel

Journal:

Investigative Opthalmology & Visual Science

Année:

2016

Fichier:

PDF, 1.06 MB

2016

Inhibition of the alternative complement pathway accelerates repair processes in the murine model of choroidal neovascularization

Parsons, Nathaniel, Annamalai, Balasubramaniam, Obert, Elisabeth, Schnabolk, Gloriane, Tomlinson, Stephen, Rohrer, Bärbel

Journal:

Molecular Immunology

Année:

2019

Langue:

english

Fichier:

PDF, 1.44 MB

english, 2019

Increased Nonexudative Age-Related Macular Degeneration Diagnosis Among Medicare Beneficiaries With Rheumatoid Arthritis

Schnabolk, Gloriane, Rohrer, Bärbel, Simpson, Kit N.

Journal:

Investigative Opthalmology & Visual Science

Année:

2019

Fichier:

PDF, 488 KB

2019

Mechanisms of extracellular vesicle uptake in stressed retinal pigment epithelial cell monolayers

Nicholson, Crystal, Shah, Navjot, Ishii, Masaaki, Annamalai, Balasubramaniam, Brandon, Carlene, Rodgers, Jessalyn, Nowling, Tamara, Rohrer, Bärbel

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Année:

2019

Langue:

english

Fichier:

PDF, 10.31 MB

english, 2019